GLG 598/490 xxxSpring '00

ATTACHED CELLS

EARLY FINDINGS

• Rat/chick bone cells may decrease activity as indicated by glucose utilization, cytoskeletal changes, and 45% reduction in mRNA expression of type I Col and OC
• Chick muscle fibers decrease their rate of protein synthesis and lose fiber mass
• Arg-Gly-Asp-Ser (RGDS) inhibits gravisensing in Chara corallina in a concentration-dependent manner

Hughes-Fulford M, Lewis M. 1996.ÝÝEffects of microgravity on osteoblast growth activation. Exp Cell Res. 224:103-9.

Landis WJ. An overview of vertebrate mineralization with emphasis on collagen-mineral interaction. Gravitational Space Bio. Bull. 12:15-26, 1999.

Vandenburgh H, Chromiak J, Shansky J, Del Tatto M, Lemaire J. 1999. Space travel directly induces skeletal muscle atrophy. FASEB J. 13:1031-1038.

Wayne, R., M. P. Staves, and A. C. Leopold. The contribution of the extracellular matrix to gravisensing in characean cells. J. Cell Sci. 101:611-623, 1992.

Cell & molecular biology research in space. FASEB J. 13 (Suppl.), S1-S177, 1999.

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